Libyan Journal of Medicine
pISSN 1993-2820    eISSN 1819-6357
Current issue
Archival Issues
Journal Abstract
Amelioration of lead induced hepatotoxicity by Allium sativum extracts in Swiss albino mice
A Sharma 1, V Sharma 1, L Kansal  1
1 - Department of Bioscience and Biotechnology, Banasthali University, Banasthali, India
Libyan J Med 2010; 5 0-0
aaICID: 897714
Article type: Original article
IC™ Value: 3.00
Abstract provided by Publisher
Lead is a blue-gray and highly toxic divalent metal that occurs naturally in the earth crust and is spread throughout the environment by various human activities. The efficacy of garlic (Allium sativum) to reduce hepatotoxicity induced by lead nitrate was evaluated experimentally in male mice. Oral treatment with lead nitrate at a dose of 50 mg/ kg body weight daily for 40 days (1/45 of LD50) induced a significant increase in the levels of hepatic aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ALP), cholesterol, lipid peroxidation (LPO) and lead nitrate. In parallel, hepatic protein levels in lead exposed mice were significantly depleted. Lead nitrate exposure also produced detrimental effects on the redox status of the liver indicated by a significant decline in the levels of liver antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH). After exposure to lead nitrate (50 mg/kg body weight for 10 days), the animals received aqueous garlic extract (250 mg/ kg body weight and 500 mg/ kg body weight) and ethanolic garlic extract (100 mg/ kg body weight and 250 mg/ kg body weight) and partially restored the deranged parameters significantly Histological examination of the liver also revealed pathophysiological changes in lead nitrate exposed group and treatment with garlic improved liver histology. Our data suggest that garlic is a phytoantioxidant that can counteract the deleterious effects of lead nitrate.

ICID 897714

DOI 10.4176/091107

Related articles
  • in IndexCopernicus™
         Lead [304 related records]
         Allium sativum [4 related records]
         Lipid Peroxidation [476 related records]
         marker enzymes [1 related records]
         hepatotoxicity [10 related records]
         Metal estimation [0 related records]

    Comments: 0
    Published remarks are private opinions of the users.
    Editorial office of the service do not take responsibility for them.

    Copyright © Libyan Journal of Medicine  2019
    Page created by Index Copernicus Ltd. All Rights reserved.