Quantitative analysis of Gallstones in Libyan Patients AM Jarari 1, JR Peela 1, TN Patil 1, A Hai 1, HA Awamy 1, SO El Saeity 2, EB AbdelKafi 2, MN El Hemri 2, MF Tayesh 2 1 - Department of Biochemistry, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya 2 - Department of Surgery, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya
Libyan J Med 2010; 5 0-0 aaICID: 896812
Article type: Original article
IC™ Value: 3.00
Abstract provided by Publisher
Gall stone disease is one of the major surgical problems in the Libyan population; it is probably related to diet, especially excessive consumption of meat. The study was conducted to determine the composition of gallstones and their possible etiology in a Libyan population. The chemical composition of gallstones from 41 patients (6 males and 35 females) was analyzed. The stones were classified into cholesterol, pigment and mixed stones. Cholesterol stones showed a significantly higher cholesterol content than pigment stones (p=0.0085) though not significantly higher than mixed stones. Their phospholipid content and inorganic phosphates were higher than in the other types of stones; and oxalate content was significantly elevated in comparison with mixed stones (p=0.0471). In mixed stones, the cholesterol, bile acids and bilirubin were intermediate between cholesterol and pigment stones whereas triglycerides were significantly more than pigment stones (p=0.0004). Bilirubin (0.0001) and bile acids (p=0.0009) were significantly higher than cholesterol stones (p=0.0001). However, they contained the lowest amounts of sodium, potassium, magnesium and oxalate. In pigment stones, bilirubin (p=0.0001) was significantly higher than both groups. Bile acid content was significantly higher than cholesterol stones (p=0.0001) but not significantly more than mixed stones. They showed the highest values of calcium, sodium, potassium, magnesium and chlorides compared to the other types of stones. High levels of cholesterol in stones and dyslipidemia associated with mixed as well as cholesterol gall stones suggest an etiological association and efforts to reduce dietary fat among the Libyan population may lead to decreased cholesterol and mixed gallstones.